Interferon-α enhances the IL-12-induced STAT4 activation selectively in carriers of the STAT4 SLE risk allele rs7574865[T]

Ann Rheum Dis. 2019 Mar;78(3):429-431. doi: 10.1136/annrheumdis-2018-213836. Epub 2018 Sep 29.
No abstract available

Keywords: T cells; gene polymorphism; systemic lupus erythematosus.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Interferon-alpha / physiology*
  • Interleukin-12 / physiology*
  • Lupus Erythematosus, Systemic / genetics*
  • Phosphorylation / genetics
  • Polymorphism, Single Nucleotide
  • STAT4 Transcription Factor / genetics*
  • Transcriptional Activation / genetics*

Substances

  • Interferon-alpha
  • STAT4 Transcription Factor
  • Interleukin-12