Cardiology relies on a huge amount of data derived from clinical observations, case-specific considerations and randomised controlled trials. At best, medical intervention relieves symptoms and reduces disease consequences or complications. Rarely, it redirects the cause. However, an accelerated array of opportunities within a digital and molecular discourse may mark a medical era which acknowledges individual variation rather than accepts a pragmatic pooling of similarities. This review aims at providing a brief overview of academic achievements, clinical considerations and translational perspectives related to precision cardiology.