Glucocorticoids is a type of steroid hormone secreted from zona fasciculata of adrenal cortex.As an immune and inflammatory inhibitor, glucocorticoids has been used to treat many kinds of diseases.T cell response plays a crucial role in the pathogenesis of liver diseases. However, the role of glucocorticoids in the mechanism and treatment of liver disease in current clinical practice is controversial. This paper summarizes the progress of glucocorticoid use for the treatment of liver diseases in recent years. References will be provided for how to grasp the indications,application timing and proper dosage of glucocorticoids in liver diseases.
糖皮质激素是由肾上腺皮质束状带分泌的一类甾体激素，具有抑制免疫及炎症反应的功能，被广泛应用于多种疾病。T淋巴细胞应答在肝脏疾病的发病机制中占有重要地位，因此，糖皮质激素在肝脏疾病发病及治疗中的角色长期以来备受关注。现就糖皮质激素在肝脏疾病发病及治疗中的最新进展进行总结及评述，对如何在临床工作中更好地把握糖皮质激素在肝脏疾病中的适应证、应用时机、恰当剂量以及扩大其在患者中的受益等提供参考建议。.
Keywords: Glucocorticoids; Hepatic failure; Hepatitis; Liver diseases; Liver transplantation.