Clinical implementations of 4D pencil beam scanned particle therapy: Report on the 4D treatment planning workshop 2016 and 2017

Petra Trnková; Barbara Knäusl; Oxana Actis; Christoph Bert; Aleksandra K Biegun; Till T Boehlen; Hugo Furtado; Jamie McClelland; Shinichiro Mori; Ilaria Rinaldi; Antoni Rucinski; Antje C Knopf

doi:10.1016/j.ejmp.2018.10.002

Clinical implementations of 4D pencil beam scanned particle therapy: Report on the 4D treatment planning workshop 2016 and 2017

Phys Med. 2018 Oct:54:121-130. doi: 10.1016/j.ejmp.2018.10.002. Epub 2018 Oct 8.

Authors

Affiliations

¹ HollandPTC, P.O. Box 5046, 2600 GA Delft, the Netherlands; Erasmus MC, P.O. Box 5201, 3008 AE Rotterdam, the Netherlands.
² Department of Radiation Oncology, Division of Medical Radiation Physics, Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University of Vienna/AKH Vienna, Austria.
³ Paul Scherrer Institute (PSI), 5232 Villigen, Switzerland.
⁴ Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany.
⁵ KVI-Center for Advanced Radiation Technology, University of Groningen, Groningen, the Netherlands.
⁶ Centre for Medical Image Computing, Dept. Medical Physics and Biomedical, University College London, London, UK.
⁷ National Institute of Radiological Sciences for Charged Particle Therapy, Chiba, Japan.
⁸ Lyon 1 University and CNRS/IN2P3, UMR 5822, 69622 Villeurbanne, France; MAASTRO Clinic, P.O. Box 3035, 6202 NA Maastricht, the Netherlands.
⁹ Institute of Nuclear Physics PAN, Krakow, Poland.
¹⁰ University of Groningen, University Medical Center Groningen, Department of Radiation Oncology, Groningen, the Netherlands. Electronic address: a.c.knopf@umcg.nl.

PMID: 30337001
DOI: 10.1016/j.ejmp.2018.10.002

Abstract

In 2016 and 2017, the 8th and 9th 4D treatment planning workshop took place in Groningen (the Netherlands) and Vienna (Austria), respectively. This annual workshop brings together international experts to discuss research, advances in clinical implementation as well as problems and challenges in 4D treatment planning, mainly in spot scanned proton therapy. In the last two years several aspects like treatment planning, beam delivery, Monte Carlo simulations, motion modeling and monitoring, QA phantoms as well as 4D imaging were thoroughly discussed. This report provides an overview of discussed topics, recent findings and literature review from the last two years. Its main focus is to highlight translation of 4D research into clinical practice and to discuss remaining challenges and pitfalls that still need to be addressed and to be overcome.

Keywords: 4D dosimetry; 4D imaging; Moving targets; Proton therapy.

MeSH terms

Four-Dimensional Computed Tomography*
Monte Carlo Method
Movement
Phantoms, Imaging
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted / methods*

Grants and funding

21993/CRUK_/Cancer Research UK/United Kingdom