Phosphatidic Acid Signals via the Hippo Pathway

Eleni Stampouloglou; Xaralabos Varelas

doi:10.1016/j.molcel.2018.10.004

Phosphatidic Acid Signals via the Hippo Pathway

Mol Cell. 2018 Oct 18;72(2):205-206. doi: 10.1016/j.molcel.2018.10.004.

Authors

Eleni Stampouloglou¹, Xaralabos Varelas²

Affiliations

¹ Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA.
² Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA. Electronic address: xvarelas@bu.edu.

PMID: 30340020
DOI: 10.1016/j.molcel.2018.10.004

Abstract

In this issue of Molecular Cell, Han et al. (2018) show that phosphatidic acid inhibits the action of the LATS kinases, key mediators of Hippo pathway signaling, which leads to an increase in the nuclear activity of the transcriptional regulator YAP.

Publication types

Comment

MeSH terms

Adaptor Proteins, Signal Transducing*
Phosphatidic Acids
Phosphoproteins
Protein Serine-Threonine Kinases*
Signal Transduction

Substances

Adaptor Proteins, Signal Transducing
Phosphatidic Acids
Phosphoproteins
Protein Serine-Threonine Kinases

Grants and funding

R01 HL124392/HL/NHLBI NIH HHS/United States