Etiology of Balkan Endemic Nephropathy: An Update on Aristolochic Acids Exposure Mechanisms

Chem Res Toxicol. 2018 Nov 19;31(11):1109-1110. doi: 10.1021/acs.chemrestox.8b00291. Epub 2018 Oct 22.

Abstract

Aristolochic acid released from decaying Aristolochia clematitis weed is contaminating soil and food crops in Eastern Europe and is one of the major causes to Balkan endemic nephropathy. Measures should be taken to prevent people from being exposed to these highly potent phytotoxins. Research needs to develop remediation methods.

MeSH terms

  • Aristolochia / chemistry*
  • Aristolochia / growth & development
  • Aristolochia / metabolism
  • Aristolochic Acids / toxicity*
  • Balkan Nephropathy / etiology*
  • Crops, Agricultural / drug effects
  • Crops, Agricultural / growth & development
  • Crops, Agricultural / metabolism
  • Humans
  • Soil Pollutants / chemistry*
  • Soil Pollutants / toxicity
  • Water Pollutants / chemistry
  • Water Pollutants / toxicity

Substances

  • Aristolochic Acids
  • Soil Pollutants
  • Water Pollutants