The Common Key to Class-Switch Recombination and Somatic Hypermutation: Discovery of AID and Its Role in Antibody Gene Diversification

J Immunol. 2018 Nov 1;201(9):2527-2529. doi: 10.4049/jimmunol.1801246.

Authors

Rebecca J Leeman-Neill^{1

2}, Junghyun Lim¹, Uttiya Basu³

Affiliations

¹ Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032; and.
² Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032.
³ Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032; and ub2121@cumc.columbia.edu.

No abstract available

Publication types

Classical Article
Historical Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
B-Lymphocytes / cytology
B-Lymphocytes / immunology*
Cell Line
Cytidine Deaminase / genetics*
Genes, Immunoglobulin / genetics
Genes, Immunoglobulin / immunology
History, 20th Century
History, 21st Century
Humans
Hyper-IgM Immunodeficiency Syndrome / genetics
Immunoglobulin Class Switching / genetics*
Immunoglobulin Class Switching / immunology
Mice
Somatic Hypermutation, Immunoglobulin / genetics*
Somatic Hypermutation, Immunoglobulin / immunology

Substances

AICDA (activation-induced cytidine deaminase)
Cytidine Deaminase

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