The prescription rates of glucagon for hypoglycemia by pediatricians and physicians are low in Japan

Endocrine. 2019 May;64(2):233-238. doi: 10.1007/s12020-018-1793-z. Epub 2018 Oct 26.

Abstract

Purpose: Hypoglycemia is a common and life-threatening complication in type 1 diabetes mellitus (T1DM) patients. Current guidelines recommend glucagon for treating hypoglycemia in out-of-hospital settings; however, glucagon is reportedly underused in such patients. We conducted a doctor-oriented, questionnaire-based survey of pediatricians and physicians to determine the glucagon prescription rate and identify the reason(s) for its underuse in T1DM patients.

Methods: A questionnaire was mailed to 415 pediatricians and 200 physicians employed at 66 facilities with >100 general wards throughout Hyogo, Japan. The following variables were surveyed: doctor's specialty, glucagon prescription rate, familiarity with glucagon use guidelines, barriers to prescribing glucagon, and attitude changes after education.

Results: After 16 doctors were found to have retired, 599 doctors were enrolled; 305 (187 pediatricians and 118 physicians) returned a completed questionnaire. In all, 45 pediatricians and 104 physicians were treating T1DM patients, of whom 24% and 28% reported prescribing glucagon, respectively. The guideline familiarity rate among pediatricians was lower than that among physicians. The major barrier to prescribing glucagon was the complex preparation procedure required by patients/caregivers. More than half of the doctors who did not prescribe glucagon began doing so after being educated about the guidelines.

Conclusion: The glucagon prescription rate was low among both pediatricians and physicians in Japan.

Keywords: Glucagon; Guideline; Prescription; Type 1 diabetes mellitus.

MeSH terms

  • Adult
  • Child
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 1 / blood*
  • Diabetes Mellitus, Type 1 / complications
  • Drug Prescriptions / statistics & numerical data*
  • Female
  • Glucagon / therapeutic use*
  • Health Care Surveys
  • Humans
  • Hypoglycemia / blood
  • Hypoglycemia / drug therapy*
  • Hypoglycemia / etiology
  • Japan
  • Male
  • Practice Patterns, Physicians' / statistics & numerical data*

Substances

  • Glucagon