Mechanisms of synergistic neurotoxicity induced by two high risk pesticide residues - Chlorpyrifos and Carbofuran via oxidative stress

Toxicol In Vitro. 2019 Feb:54:338-344. doi: 10.1016/j.tiv.2018.10.016. Epub 2018 Oct 30.

Abstract

Multi-component pesticide residues, especially pesticide residues with synergistic toxicity, are a serious threat to food safety. With risk assessment, we found that Chlorpyrifos (CPF) and Carbofuran (CBF) are 2 pesticide residues with highest risk for Actinidia chinensis planch. The results showed CPF and CBF have a synergistic neurotoxicity on neural cell SK-N-SH. The toxicity was partly depending on oxidative stress (OS) and had effects on cell apoptosis and cell cycle arrest. Furthermore, the toxicity remained on long-term low-dose condition.

Keywords: Apoptosis; Carbofuran; Chlorpyrifos; Cycle arrest; Oxidative stress; Synergistic neurotoxicity.

MeSH terms

  • Actinidia
  • Apoptosis / drug effects
  • Carbofuran / analysis
  • Carbofuran / toxicity*
  • Cell Line, Tumor
  • Chlorpyrifos / analysis
  • Chlorpyrifos / toxicity*
  • Cholinesterase Inhibitors / analysis
  • Cholinesterase Inhibitors / toxicity*
  • Drug Synergism
  • Food Contamination / analysis
  • Humans
  • Insecticides / analysis
  • Insecticides / toxicity*
  • Oxidative Stress / drug effects
  • Pesticide Residues / analysis
  • Pesticide Residues / toxicity*
  • Risk Assessment

Substances

  • Cholinesterase Inhibitors
  • Insecticides
  • Pesticide Residues
  • Chlorpyrifos
  • Carbofuran