Mice from Same-Sex Parents: CRISPRing Out the Barriers for Unisexual Reproduction

Ido Sagi; Shiran Bar; Nissim Benvenisty

doi:10.1016/j.stem.2018.10.012

Mice from Same-Sex Parents: CRISPRing Out the Barriers for Unisexual Reproduction

Cell Stem Cell. 2018 Nov 1;23(5):625-627. doi: 10.1016/j.stem.2018.10.012.

Authors

Ido Sagi¹, Shiran Bar¹, Nissim Benvenisty²

Affiliations

¹ The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.
² The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel. Electronic address: nissimb@mail.huji.ac.il.

PMID: 30388415
DOI: 10.1016/j.stem.2018.10.012

Abstract

Genomic imprinting results in the molecular and functional inequality of maternal and paternal alleles, precluding mammalian unisexual development. In this issue of Cell Stem Cell, Li et al. (2018) employ sophisticated manipulations of gametes and engineered haploid embryonic stem cells to successfully generate both all-maternal and all-paternal mice, effectively overcoming the roadblocks of imprinting.

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MeSH terms

Alleles
Animals
Genomic Imprinting*
Haploidy
Humans
Mice
Parents
Reproduction*