The Harmful Consequences of Increased Fitness in Hematopoietic Stem Cells

Megan E McNerney; Michelle M Le Beau

doi:10.1016/j.stem.2018.10.003

The Harmful Consequences of Increased Fitness in Hematopoietic Stem Cells

Cell Stem Cell. 2018 Nov 1;23(5):634-635. doi: 10.1016/j.stem.2018.10.003.

Authors

Megan E McNerney¹, Michelle M Le Beau²

Affiliations

¹ Department of Pathology and the Department of Pediatrics, The University of Chicago, Chicago, IL 60637, USA; University of Chicago Medicine Comprehensive Cancer Center, Chicago, IL 60637, US.
² Department of Medicine, The University of Chicago, Chicago, IL 60637, USA; University of Chicago Medicine Comprehensive Cancer Center, Chicago, IL 60637, US. Electronic address: mlebeau@bsd.uchicago.edu.

PMID: 30388419
DOI: 10.1016/j.stem.2018.10.003

Abstract

Clonal hematopoiesis of indeterminate potential (CHIP) describes clonal selection of a hematopoietic stem cell with a somatic mutation that confers increased fitness, influenced by a selective environment such as aging, inflammation, or therapeutic exposure. In this issue of Cell Stem Cell, Hsu et al. (2018) explore the role of cytotoxic therapy in disease-relevant CHIP.

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MeSH terms

Hematopoiesis
Hematopoietic Stem Cell Transplantation*
Hematopoietic Stem Cells*
Humans
Inflammation
Mutation
Protein Phosphatase 2C

Substances

PPM1D protein, human
Protein Phosphatase 2C