Essential Characteristics of Pharmacogenomics Study Publications

Caroline F Thorn; Michelle Whirl-Carrillo; Houda Hachad; Julie A Johnson; Ellen M McDonagh; Mark J Ratain; Mary V Relling; Stuart A Scott; Russ B Altman; Teri E Klein

doi:10.1002/cpt.1279

Essential Characteristics of Pharmacogenomics Study Publications

Clin Pharmacol Ther. 2019 Jan;105(1):86-91. doi: 10.1002/cpt.1279.

Authors

Affiliations

¹ Department of Biomedical Data Sciences, Stanford University, Stanford, California, USA.
² Translational Software, Bellevue, Washington, USA.
³ College of Pharmacy, University of Florida, Gainesville, Florida, USA.
⁴ Genomics England, Queen Mary University of London, London, UK.
⁵ Department of Medicine, The University of Chicago, Chicago, Illinois, USA.
⁶ Pharmaceutical Department, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
⁷ Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
⁸ Sema4, a Mount Sinai Venture, Stamford, Connecticut, USA.
⁹ Department of Genetics, Department of Computer Science, Department of Biomedical Engineering, Stanford University, Stanford, California, USA.
¹⁰ Department of Medicine, Stanford University, Stanford, California, USA.

Abstract

Pharmacogenomics (PGx) can be seen as a model for biomedical studies: it includes all disease areas of interest and spans in vitro studies to clinical trials, while focusing on the relationships between genes and drugs and the resulting phenotypes. This review will examine different characteristics of PGx study publications and provide examples of excellence in framing PGx questions and reporting their resulting data in a way that maximizes the knowledge that can be built on them.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Humans
Periodicals as Topic* / trends
Pharmacogenetics / methods*
Pharmacogenetics / trends
Terminology as Topic*
Translational Research, Biomedical / methods*
Translational Research, Biomedical / trends

Abstract

Publication types

MeSH terms

Grants and funding