Increased Plasma Levels of Gut-Derived Phenolics Linked to Walking and Running Following Two Weeks of Flavonoid Supplementation

Nutrients. 2018 Nov 9;10(11):1718. doi: 10.3390/nu10111718.

Abstract

Using a randomized, double-blinded, placebo-controlled, parallel group design, this investigation determined if the combination of two weeks of flavonoid supplementation (329 mg/day, quercetin, anthocyanins, flavan-3-ols mixture) and a 45-minute walking bout (62.2 ± 0.9% VO2max (maximal oxygen consumption rate)) enhanced the translocation of gut-derived phenolics into circulation in a group of walkers (n = 77). The walkers (flavonoid, placebo groups) were randomized to either sit or walk briskly on treadmills for 45 min (thus, four groups: placebo⁻sit, placebo⁻walk, flavonoid⁻sit, flavonoid⁻walk). A comparator group of runners (n = 19) ingested a double flavonoid dose for two weeks (658 mg/day) and ran for 2.5 h (69.2 ± 1.2% VO2max). Four blood samples were collected (pre- and post-supplementation, immediately post- and 24 h post-exercise/rest). Of the 76 metabolites detected in this targeted analysis, 15 increased after the 2.5 h run, and when grouped were also elevated post-exercise (versus placebo⁻sit) for the placebo⁻ and flavonoid⁻walking groups (p < 0.05). A secondary analysis showed that pre-study plasma concentrations of gut-derived phenolics in the runners were 40% higher compared to walkers (p = 0.031). These data indicate that acute exercise bouts (brisk walking, intensive running) are linked to an increased translocation of gut-derived phenolics into circulation, an effect that is amplified when combined with a two-week period of increased flavonoid intake or chronic training as a runner.

Keywords: colon; exercise; hippurate; intestinal tract; metabolite; polyphenol.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Dietary Supplements*
  • Double-Blind Method
  • Exercise Test
  • Female
  • Flavonoids / blood
  • Flavonoids / pharmacokinetics
  • Flavonoids / pharmacology*
  • Humans
  • Male
  • Oxygen Consumption
  • Phenols / blood
  • Physical Exertion
  • Plasma
  • Polyphenols / blood*
  • Running / physiology*
  • Walking / physiology*

Substances

  • Flavonoids
  • Phenols
  • Polyphenols

Grants and funding