Genomic updates in understanding PTSD

Sumeet Sharma; Kerry J Ressler

doi:10.1016/j.pnpbp.2018.11.010

Genomic updates in understanding PTSD

Prog Neuropsychopharmacol Biol Psychiatry. 2019 Mar 2:90:197-203. doi: 10.1016/j.pnpbp.2018.11.010. Epub 2018 Nov 16.

Authors

Sumeet Sharma¹, Kerry J Ressler²

Affiliations

¹ Neuroscience Program, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, United States; McLean Hospital, Division of Depression and Anxiety, Belmont, MA, United States.
² McLean Hospital, Division of Depression and Anxiety, Belmont, MA, United States; Harvard Medical School, Boston, MA, United States; Neuroscience Program, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, United States. Electronic address: kressler@mclean.harvard.edu.

Abstract

Twin studies as well as more recent genetics-based heritability analyses demonstrate that up to 40 to 50% of the variance in predicting PTSD following trauma is heritable. However, most of the specific gene pathways and mechanism that mediate risk vs. resilience for PTSD following trauma exposure have yet to be elucidated. This review will examine the latest results from large scale Genome-wide association studies as well as other approaches aimed at understanding mechanisms of development of and recovery from PTSD.

Keywords: Anxiety; Depression; Epigenetic; Gene-by-environment interaction; PTSD; Stress; Trauma.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Gene-Environment Interaction
Genetic Predisposition to Disease
Humans
Stress Disorders, Post-Traumatic / genetics*

Abstract

Publication types

MeSH terms

Grants and funding