Salvage Debridement, Antibiotics and Implant Retention ("DAIR") With Local Injection of a Selected Cocktail of Bacteriophages: Is It an Option for an Elderly Patient With Relapsing Staphylococcus aureus Prosthetic-Joint Infection?

Tristan Ferry; Gilles Leboucher; Cindy Fevre; Yannick Herry; Anne Conrad; Jérôme Josse; Cécile Batailler; Christian Chidiac; Mathieu Medina; S Lustig; Frédéric Laurent; Lyon BJI Study Group

doi:10.1093/ofid/ofy269

Salvage Debridement, Antibiotics and Implant Retention ("DAIR") With Local Injection of a Selected Cocktail of Bacteriophages: Is It an Option for an Elderly Patient With Relapsing Staphylococcus aureus Prosthetic-Joint Infection?

Open Forum Infect Dis. 2018 Oct 24;5(11):ofy269. doi: 10.1093/ofid/ofy269. eCollection 2018 Nov.

Authors

Tristan Ferry^{1

2

3

4}, Gilles Leboucher⁵, Cindy Fevre⁶, Yannick Herry^{2

4

7}, Anne Conrad^{1

2

3

4}, Jérôme Josse^{2

3

4

8}, Cécile Batailler^{2

4

7}, Christian Chidiac^{1

2

3

4}, Mathieu Medina⁶, S Lustig⁷, Frédéric Laurent^{2

3

4

8}; Lyon BJI Study Group

Collaborators

Lyon BJI Study Group:
Tristan Ferry, Tristan Ferry, Florent Valour, Thomas Perpoint, André Boibieux, François Biron, Patrick Miailhes, Florence Ader, Agathe Becker, Sandrine Roux, Claire Triffault-Fillit, Anne Conrad, Alexie Bosch, Fatiha Daoud, Johanna Lippman, Evelyne Braun, Christian Chidiac, Sébastien Lustig, Elvire Servien, Romain Gaillard, Antoine Schneider, Stanislas Gunst, Cécile Batailler, Michel-Henry Fessy, Jean-Luc Besse, Yannick Herry, Anthony Viste, Philippe Chaudier, Cyril Courtin, Lucie Louboutin, Sébastien Martres, Franck Trouillet, Cédric Barrey, Emmanuel Jouanneau, Timothée Jacquesson, Ali Mojallal, Fabien Boucher, Hristo Shipkov, Joseph Chateau, Frédéric Aubrun, Mikhail Dziadzko, Caroline Macabéo, Frederic Laurent, Laeticia Beraud, Jérôme Josse, Camille Kolenda, Céline Dupieux, Fabien Craighero, Loic Boussel, Jean-Baptiste Pialat, Isabelle Morelec, Marc Janier, Francesco Giammarile, Michel Tod, Marie-Claude Gagnieu, Sylvain Goutelle, Béatrice Grisi, Cédric Dananche, Eugénie Mabrut

Affiliations

¹ Service de Maladies Infectieuses, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, France.
² Université Claude Bernard Lyon 1, France.
³ Centre International de Recherche en Infectiologie, Lyon, France.
⁴ Centre Interrégional de Référence des Infections Ostéo-Articulaires Complexes (CRIOAc Lyon), Hospices Civils de Lyon, France.
⁵ Pharmacie, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, France.
⁶ Pherecydes Pharma, Romainville, France.
⁷ Service de Chirurgie Orthopédique, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, France.
⁸ Laboratoire de Bactériologie, Institut des Agents Infectieux, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, France.

Abstract

Local injection of a bacteriophages mix during debridement, antibiotics and implant retention ("DAIR") was performed to treat a relapsing Staphylococcus aureus chronic prosthetic joint infection (PJI). This salvage treatment was safe and associated with a clinical success. Scientific evaluation of the potential clinical benefit of bacteriophages as antibiofilm treatment in PJI is now feasible and required.

Keywords: DAIR; S. aureus; bacteriophage; prosthetic-joint infection; suppressive therapy.