Is the absence of alpha-helix 2 in the appendant structure region the major contributor to structural instability of human cystatin C?

J Biomol Struct Dyn. 2019 Oct;37(17):4522-4527. doi: 10.1080/07391102.2018.1552625. Epub 2019 Jan 16.

Authors

Xuejie Zhou¹, Xian Lu¹, Shuzhen Qin¹, Linan Xu², Xiaoying Chong¹, Junqing Liu¹, Pingyu Yan¹, Rui Sun¹, Ian P Hurley³, Gary W Jones³, Qiuyu Wang¹, Jianwei He¹

Affiliations

¹ School of Life Science, Liaoning University , Shenyang , China.
² Department of Biology, Maynooth University , Maynooth , County Kildare , Ireland.
³ Centre for Biomedical Science Research, School of Clinical and Applied Sciences, Faculty of Health and Social Sciences, Leeds Beckett University , Leeds , United Kingdom.

PMID: 30484377
DOI: 10.1080/07391102.2018.1552625

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Animals
Chickens
Cystatin C / chemistry*
Humans
Hydrophobic and Hydrophilic Interactions
Molecular Dynamics Simulation
Protein Conformation, alpha-Helical
Protein Multimerization
Protein Stability
Recombinant Proteins / chemistry
Structural Homology, Protein

Substances

CST3 protein, human
Cystatin C
Recombinant Proteins