Malignant Sweat Gland Tumors

Christine S Ahn; Omar P Sangüeza

doi:10.1016/j.hoc.2018.09.002

Malignant Sweat Gland Tumors

Hematol Oncol Clin North Am. 2019 Feb;33(1):53-71. doi: 10.1016/j.hoc.2018.09.002.

Authors

Christine S Ahn¹, Omar P Sangüeza²

Affiliations

¹ Department of Pathology, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA.
² Department of Pathology, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA. Electronic address: osanguez@wakehealth.edu.

PMID: 30497677
DOI: 10.1016/j.hoc.2018.09.002

Abstract

Malignant sweat gland neoplasms are a confusing area within dermatopathology, with many entities reported under several designations in the literature. This review describes the key clinical and histopathologic features of select malignant adnexal neoplasms, including porocarcinoma, papillary carcinoma, adenoid cystic carcinoma, cribriform carcinoma, apocrine hidradenocarcinoma, malignant mixed tumor of the skin, syringoid carcinoma, cylindrocarcinoma, spiradenocarcinoma, mucinous carcinoma, polymorphous sweat gland carcinoma, microcystic adnexal carcinoma, secretory carcinoma of the skin, and primary cutaneous signet ring cell carcinoma. For entities with overlapping features, differential diagnoses are discussed.

Keywords: Cutaneous; Cylindrocarcinoma; Hidradenocarcinoma; Pilomatrixcarcinoma; Porocarcinoma.

Publication types

Review

MeSH terms

Biopsy
Diagnosis, Differential
Disease Management
Humans
Immunohistochemistry
Neoplasm Grading
Neoplasm Staging
Sweat Gland Neoplasms / diagnosis*
Sweat Gland Neoplasms / etiology
Sweat Gland Neoplasms / therapy