Effective angiogenesis requires regulation of phosphoinositide signaling

Adv Biol Regul. 2019 Jan:71:69-78. doi: 10.1016/j.jbior.2018.11.008. Epub 2018 Nov 26.

Abstract

Phosphoinositide signaling regulates numerous downstream effectors that mediate cellular processes which influence cell cycle progression, migration, proliferation, growth, survival, metabolism and vesicular trafficking. A prominent role for phosphoinositide 3-kinase, which generates phosphatidylinositol 3,4,5-trisphosphate, a phospholipid that activates a plethora of effectors including AKT and FOXO during embryonic and postnatal angiogenesis, has been described. In addition, phosphatidylinositol 3-phosphate signaling is required for endosomal trafficking, which contributes to vascular remodeling. This review will examine the role phosphoinositide signaling plays in the endothelium and its contribution to sprouting angiogenesis.

Keywords: Angiogenesis; PI3K; PTEN; Phosphoinositide.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Forkhead Transcription Factors / metabolism
  • Humans
  • Neovascularization, Physiologic / physiology*
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Phosphatidylinositol Phosphates / metabolism*
  • Proto-Oncogene Proteins c-akt / metabolism
  • Signal Transduction / physiology*

Substances

  • Forkhead Transcription Factors
  • Phosphatidylinositol Phosphates
  • phosphatidylinositol 3,4,5-triphosphate
  • Proto-Oncogene Proteins c-akt