Self-assembling and biological properties of single-chain dicationic pyridinium-based surfactants

Colloids Surf B Biointerfaces. 2019 Mar 1:175:351-357. doi: 10.1016/j.colsurfb.2018.12.010. Epub 2018 Dec 6.

Abstract

In this work, the dicationic surfactants containing viologen and vinylbipyridinium moieties and hexadecyl chains were synthesized, and their aggregation behavior in water solutions was investigated by surface tension, conductivity measurements, hydrophobic probe solubilization, dynamic light scattering and electrophoretic measurements. Effect of UV-light on cis-trans isomerism of vinylbipyridinium derivative was determined. Antimicrobial activity and the influence of these surfactants on cell viability depended on the concentration and type of surfactant used. The results obtained established the structure-property (physicochemical properties and biological activity) relationship of the surfactant molecule namely the primary role of pyridinium head group structure.

Keywords: Antimicrobial activity; Self-assembly; Solubilization; Surfactant; Toxicity.

MeSH terms

  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / pharmacology*
  • Bacteria / drug effects*
  • Cations / chemistry*
  • Fungi / drug effects*
  • Pyridines / chemistry*
  • Surface-Active Agents / chemistry
  • Surface-Active Agents / pharmacology*

Substances

  • Anti-Infective Agents
  • Cations
  • Pyridines
  • Surface-Active Agents