Skeletal fragility: an emerging complication of Ehlers-Danlos syndrome

Endocrine. 2019 Feb;63(2):225-230. doi: 10.1007/s12020-018-1822-y. Epub 2018 Dec 15.

Abstract

Ehlers-Danlos syndrome (EDS) is an emerging cause of skeletal fragility. Mechanism of bone damage are probably multifactorial in line with the different skeletal phenotypes that can be found in clinical practice. A structured approach to clinical management of bone metabolic complication in EDS is proposed.

Keywords: Bone mineral density; Bone structure; Ehlers–Danlos syndrome; Osteoporosis; Vertebral fractures.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Bone Density / physiology*
  • Bone Diseases, Metabolic / diagnosis
  • Bone Diseases, Metabolic / drug therapy
  • Bone Diseases, Metabolic / etiology*
  • Calcium Carbonate / therapeutic use
  • Ehlers-Danlos Syndrome / complications*
  • Ehlers-Danlos Syndrome / drug therapy
  • Ehlers-Danlos Syndrome / metabolism
  • Ehlers-Danlos Syndrome / pathology
  • Female
  • Follow-Up Studies
  • Humans
  • Lumbar Vertebrae / pathology
  • Risk Factors
  • Spinal Diseases / diagnosis
  • Spinal Diseases / drug therapy
  • Spinal Diseases / etiology
  • Spinal Fractures / prevention & control
  • Vitamin D / blood
  • Vitamin D / therapeutic use
  • Vitamin D Deficiency / complications
  • Vitamin D Deficiency / diagnosis
  • Vitamin D Deficiency / drug therapy

Substances

  • Vitamin D
  • Calcium Carbonate