Sparks Fly in PGE2-Modulated Macrophage Polarization

Fabien Franco; Mathias Wenes; Ping-Chih Ho

doi:10.1016/j.immuni.2018.12.002

Sparks Fly in PGE2-Modulated Macrophage Polarization

Immunity. 2018 Dec 18;49(6):987-989. doi: 10.1016/j.immuni.2018.12.002.

Authors

Fabien Franco¹, Mathias Wenes¹, Ping-Chih Ho²

Affiliations

¹ Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland; Ludwig Cancer Research, University of Lausanne, Epalinges, Switzerland.
² Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland; Ludwig Cancer Research, University of Lausanne, Epalinges, Switzerland. Electronic address: ping-chih.ho@unil.ch.

PMID: 30566885
DOI: 10.1016/j.immuni.2018.12.002

Abstract

How macrophages convey extracellular signals by bridging metabolism and functions remains unclear. In this issue of Immunity, Sanin et al. (2018) report that prostaglandin E2 (PGE2) treatment in interleukin-4-activated macrophages suppresses mitochondrial membrane potential to control voltage-regulated genes involved in proliferation and immune responses.

Publication types

Comment

MeSH terms

Dinoprostone*
Gene Expression
Macrophages*
Membrane Potential, Mitochondrial

Substances

Dinoprostone