A case of recalcitrant pediatric Vogt-Koyanagi-Harada disease successfully controlled with adalimumab

J Formos Med Assoc. 2019 May;118(5):945-950. doi: 10.1016/j.jfma.2018.12.014. Epub 2019 Jan 5.

Abstract

Vogt-Koyanagi-Harada (VKH) disease is uncommon in the pediatric population and can have an aggressive course with serious visual sequelae. A 12-year-old Han Chinese American female, who presented with mild headaches and panuveitis with diffuse serous retinal detachments, was diagnosed with VKH. Despite treatment with a combination of high-dose systemic corticosteroids, intravitreal triamcinolone injection, and mycophenolate mofetil, ocular inflammation was inadequately controlled. Addition of adalimumab allowed for inflammation remission, improvement of vision, and tapering of systemic corticosteroids. Escalation of immunosuppression until remission appears to be critical in this population. Further research is needed to understand the complex pathophysiology of VKH and investigation for similar efficacy of other anti-tumor necrosis factor-alpha agents will need to be performed.

Keywords: Adalimumab; Mycophenolate mofetil; Pediatric; Vogt-Koyanagi-Harada (VKH).

Publication types

  • Case Reports

MeSH terms

  • Adalimumab / administration & dosage*
  • Child
  • Drug Therapy, Combination
  • Female
  • Fluorescein Angiography
  • Headache / etiology
  • Humans
  • Mycophenolic Acid / administration & dosage
  • Panuveitis / drug therapy*
  • Panuveitis / etiology
  • Remission Induction
  • Tomography, Optical Coherence
  • Triamcinolone / administration & dosage
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors
  • Uveomeningoencephalitic Syndrome / diagnosis*
  • Uveomeningoencephalitic Syndrome / drug therapy*
  • Visual Acuity

Substances

  • Tumor Necrosis Factor-alpha
  • Triamcinolone
  • Adalimumab
  • Mycophenolic Acid