Palladium-Catalyzed Carbonylative Synthesis of Isoindolinones from Benzylamines with TFBen as the CO Source

J Org Chem. 2019 Feb 1;84(3):1421-1429. doi: 10.1021/acs.joc.8b02862. Epub 2019 Jan 16.

Abstract

A palladium-catalyzed C-H carbonylation of benzylamines for the synthesis of isoindolinone scaffolds has been developed. This protocol is conducted under gas-free conditions by using benzene-1,3,5-triyl triformate (TFBen) as a convenient CO surrogate, furnishing a variety of isoindolinone derivatives in moderate to high yields (up to 95%).