The Potential of Different Origin Stem Cells in Modulating Oral Bone Regeneration Processes

Cells. 2019 Jan 8;8(1):29. doi: 10.3390/cells8010029.

Abstract

Tissue engineering has gained much momentum since the implementation of stem cell isolation and manipulation for regenerative purposes. Despite significant technical improvements, researchers still have to decide which strategy (which type of stem cell) is the most suitable for their specific purpose. Therefore, this short review discusses the advantages and disadvantages of the three main categories of stem cells: embryonic stem cells, mesenchymal stem cells and induced pluripotent stem cells in the context of bone regeneration for dentistry-associated conditions. Importantly, when deciding upon the right strategy, the selection needs to be made in concordance with the morbidity and the life-threatening level of the condition in discussion. Therefore, even when a specific type of stem cell holds several advantages over others, their availability, invasiveness of the collection method and ethical standards become deciding parameters.

Keywords: ESCs; MSCs; dentistry; iPSCs; regenerative medicine; stem cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bone Regeneration*
  • Dentistry, Operative
  • Embryonic Stem Cells* / cytology
  • Embryonic Stem Cells* / metabolism
  • Embryonic Stem Cells* / transplantation
  • Humans
  • Induced Pluripotent Stem Cells* / cytology
  • Induced Pluripotent Stem Cells* / metabolism
  • Induced Pluripotent Stem Cells* / transplantation
  • Mesenchymal Stem Cell Transplantation*
  • Mesenchymal Stem Cells* / cytology
  • Mesenchymal Stem Cells* / metabolism
  • Models, Biological
  • Mouth
  • Regenerative Medicine
  • Tissue Engineering