Probing Substrate Preferences of Depalmitoylases

Cell Chem Biol. 2019 Jan 17;26(1):3-6. doi: 10.1016/j.chembiol.2018.12.008.

Abstract

Depalmitoylases play a crucial role in regulating dynamic protein palmitoylation. In this issue of Cell Chemical Biology, Amara et al. (2019) present fluorogenic peptide probes to analyze the activity and substrate specificity of depalmitoylases and uncover that the amino acid residues distal to the palmitoylation site could regulate depalmitoylases activities.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Comment

MeSH terms

  • Amino Acids*
  • Peptides*
  • Substrate Specificity

Substances

  • Amino Acids
  • Peptides