Liquid biopsy in central nervous system metastases: a RANO review and proposals for clinical applications

Adrienne Boire; Dieta Brandsma; Priscilla K Brastianos; Emilie Le Rhun; Manmeet Ahluwalia; Larry Junck; Michael Glantz; Morris D Groves; Eudocia Q Lee; Nancy Lin; Jeffrey Raizer; Roberta Rudà; Michael Weller; Martin J Van den Bent; Michael A Vogelbaum; Susan Chang; Patrick Y Wen; Riccardo Soffietti

doi:10.1093/neuonc/noz012

Liquid biopsy in central nervous system metastases: a RANO review and proposals for clinical applications

Neuro Oncol. 2019 May 6;21(5):571-584. doi: 10.1093/neuonc/noz012.

Authors

Adrienne Boire¹, Dieta Brandsma², Priscilla K Brastianos³, Emilie Le Rhun⁴, Manmeet Ahluwalia⁵, Larry Junck⁶, Michael Glantz⁷, Morris D Groves⁸, Eudocia Q Lee⁹, Nancy Lin¹⁰, Jeffrey Raizer¹¹, Roberta Rudà¹², Michael Weller¹³, Martin J Van den Bent¹⁴, Michael A Vogelbaum¹⁵, Susan Chang¹⁶, Patrick Y Wen¹⁷, Riccardo Soffietti¹²

Affiliations

¹ Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
² Department of Neuro-Oncology, Netherlands Cancer Institute‒Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands.
³ Departments of Medicine and Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
⁴ Department of Neuro-Oncology/Neurosurgery, University Hospital, Lille, France.
⁵ Department of Medicine, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA.
⁶ Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
⁷ Department of Neurosurgery, Penn State Health, Hershey, Pennsylvania, USA.
⁸ Department of Neuro-Oncology, Austin Brain Tumor Center and University of Texas, Austin, Texas, USA.
⁹ Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
¹⁰ Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA.
¹¹ Department of Neurology and Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, USA.
¹² Department of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy.
¹³ Department of Neurology, University Hospital, Zurich, Switzerland.
¹⁴ Brain Tumor Center, Erasmus MC Cancer Center and University, Rotterdam, Netherlands.
¹⁵ Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, Ohio, USA.
¹⁶ Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA.
¹⁷ Center for Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA.

Abstract

Liquid biopsies collect and analyze tumor components in body fluids, and there is an increasing interest in the investigation of liquid biopsies as a surrogate for tumor tissue in the management of both primary and secondary brain tumors. Herein we critically review available literature on spinal fluid and plasma circulating tumor cells (CTCs) and cell-free tumor (ctDNA) for diagnosis and monitoring of leptomeningeal and parenchymal brain metastases. We discuss technical issues and propose several potential applications of liquid biopsies in different clinical settings (ie, for initial diagnosis, for assessment during treatment, and for guidance of treatment decisions). Last, ongoing clinical studies on CNS metastases that include liquid biopsies are summarized, and recommendations for future clinical studies are provided.

Keywords: CNS metastases; circulating tumor cells; clinical implications; ctDNA; liquid biopsy.

Publication types

Review

MeSH terms

Central Nervous System Neoplasms / blood
Central Nervous System Neoplasms / diagnosis*
Central Nervous System Neoplasms / genetics*
Central Nervous System Neoplasms / therapy
Circulating Tumor DNA / analysis*
Circulating Tumor DNA / genetics
Clinical Decision-Making
Humans
Liquid Biopsy / methods*
Neoplasm Metastasis
Neoplastic Cells, Circulating / metabolism
Neoplastic Cells, Circulating / pathology*
Prognosis

Substances

Circulating Tumor DNA

Abstract

Publication types

MeSH terms

Substances

Grants and funding