Objective: To investigate the clinical and prognostic differences between primary nasopharyngeal natural killer (NK)/T-cell lymphoma (NP NKTCL) and extranodal NK/T-cell lymphoma of the nasal cavity with nasopharynx extension (N-NP NKTCL). Methods: A total of 89 patients with NP NKTCL and 113 patients with N-NP NKTCL from January 2000 to June 2015 were retrospectively analyzed. Clinical and pathological features, treatment responses and prognosis were compared between the two groups. Results: NP NKTCL patients showed similar clinicopathological features with those with N-NP NKTCL, except that the former had a relative low proportion of elevated lactate dehydrogenase (LDH) levels (28.1% vs. 41.6%; P=0.001). Both of two groups presented with high proportion of cervical lymph node involvement (55.1% and 42.5%; P=0.076). The 5-year overall survival (OS) rates in these two groups were 63.2% and 54.6%, respectively, whereas 5-year progress-free survival (PFS) rates were 50.7% and 45.6%, respectively. For the patients with stage Ⅰ and Ⅱ, the 5-year OS and PFS rates in these two groups were 68.8% and 55.7% as well as 55.6% and 47.2%, respectively. These were no statistically significant differences between two groups (all P>0.05). The complete response (CR) rate after initial chemotherapy in NP NKTCL group was 43.8%, which was significant higher than that of 19.6% in N-NP NKTCL group (P=0.006). Additionally, the CR rate after primary radiotherapy was 63.4% and 62.7%, respectively (P=0.629). The NP NKTCL patients with stage Ⅰ and Ⅱ who accepted radiotherapy with or without chemotherapy had similar survival times with chemotherapy alone, showing the 5-year OS rates of 70.5% and 33.3% (P=0.238), as well as the 5-year PFS rates of 56.7% and 33.3%, respectively (P=0.431). Similar results were found in N-NP NKTCL group, the 5-year OS rates for patients with radiotherapy with or without chemotherapy and chemotherapy alone were 57.4% and 33.3% (P=0.246), while the 5-year PFS rates were 49.3% and 16.7% (P=0.177), respectively. Besides, the relapse pattern of NP NKTCL and N-NP NKTCL groups was also similar, mainly involving the distant extra-nodal organs followed by lymph nodes. Conclusion: The patients with N-NP NKTCL and NP NKTCL showed similar clinical and prognostic features, however, the initial response to chemotherapy was different.
目的： 探讨鼻咽原发和鼻咽受累结外鼻型NK/T细胞淋巴瘤患者的临床病理特征和预后。 方法： 回顾性分析2000年1月至2015年6月初治的结外鼻型NK/T细胞淋巴瘤患者的临床资料。鼻咽原发NK/T细胞淋巴瘤(鼻咽原发组)89例，鼻腔原发累及鼻咽NK/T细胞淋巴瘤(鼻咽受累组)113例，分析两组患者的临床病理特征、治疗情况和预后。采用Kaplan－Meier法和log rank检验进行生存分析。 结果： 鼻咽原发组和鼻咽受累组患者具有相似的临床病理特征，颈部淋巴结受侵比例均较高，分别为55.1%和42.5%(P＝0.076)；鼻咽原发组和鼻咽受累组患者乳酸脱氢酶升高比例分别为28.1%和41.6%，差异有统计学意义(P＝0.001)。在Ⅰ～Ⅱ期患者中，鼻咽原发组和鼻咽受累组患者的5年总生存率分别为68.8%和55.7%，差异无统计学意义(P＝0.168)；5年无进展生存率分别为55.6%和47.2%，差异无统计学意义(P＝0.241)。全组患者的5年总生存率分别为63.2%和54.6%，差异无统计学意义(P＝0.291)；5年无进展生存率分别为50.7%和45.6%，差异无统计学意义(P＝0.310)。鼻咽原发组患者初始化疗后的完全缓解率为43.8%，高于鼻咽受累组的19.6%(P＝0.006)；鼻咽原发组和鼻咽受累组患者初始放疗后的完全缓解率分别为63.4%和62.7%，差异无统计学意义(P＝0.629)。在Ⅰ～Ⅱ期鼻咽原发组患者中，放疗±化疗组和单纯化疗组患者的5年总生存率分别为70.5%和33.3%，5年无进展生存率分别为56.7%和33.3%，差异均无统计学意义(均P>0.05)；在Ⅰ～Ⅱ期鼻咽受累组患者中，放疗±化疗组和单纯化疗组患者的5年总生存率分别为57.4%和33.3%，5年无进展生存率分别为49.3%和16.7%，差异均无统计学意义(均P>0.05)。鼻咽原发组和鼻咽受累组患者的复发进展模式相似，均以远处结外器官复发进展为主，其次为淋巴结。 结论： 鼻咽原发和鼻咽受累NK/T细胞淋巴瘤患者的临床病理特征和预后相似，化疗的近期疗效不同。.
Keywords: Chemotherapy; Lymphoma, NK/T-cell; Prognosis; Radiotherapy.