Prevalence of pain in patients with cancer aged 70 years or older: A prospective observational study

J Geriatr Oncol. 2019 Jul;10(4):637-642. doi: 10.1016/j.jgo.2019.01.005. Epub 2019 Jan 25.

Abstract

Background: Pain is a common symptom among patients with cancer, yet pain prevalence and management in older cancer pts. are poorly known.

Methods: Patients aged ≥70 years referred to Istituto Oncologico Veneto IRCCS from January 2011 to December 2013 were evaluated with Comprehensive Geriatric Assessment (CGA). Pain was assessed by means of short form of McGill Pain Questionnaire (MPQ-sf), Brief Pain Inventory (BPI-sf), and numerical rating scale (NRS). Pts with completed CGA, no severe cognitive impairment and completed pain assessment were enrolled.

Results: Enrolled patients were 745; 51% male, median age 76 years, median ECOG Performance Status (PS) 1. Frail patients at CGA were 45.2%. Patients with pain were 266 (35.7%). Mean Average Pain Intensity (API) was significantly higher among females, patients fit at CGA, with advanced disease, poorer PS and more comorbidity. Pain was detected by the oncologist in 20.4% of cases and deemed cancer-related in 54.8%. Gender, PS, status of disease, stage, function disability, mood, cognitive functioning and frailty were significantly associated with reporting of pain. At BPI, moderate-severe pain was found in 81 patients. The degree of agreement between API and pain intensity evaluated by physician was minimal. Patients on pain medications were 184, with 113 patients reporting rates of pain relief ≥50%.

Conclusion: About one third of older patients with cancer report pain, which is not cancer-related in about half of cases. Female gender, fitness at CGA, advanced stage, poorer PS, higher number of comorbidities and primary site were associated with significant differences in pain reporting.

Keywords: Cancer; Elderly; Pain; Pain assessment; Pain treatment; Prevalence.

Publication types

  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Affect
  • Aged
  • Aged, 80 and over
  • Analgesics, Opioid / therapeutic use
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Cancer Pain / drug therapy
  • Cancer Pain / epidemiology*
  • Cancer Pain / physiopathology
  • Cancer Pain / psychology
  • Cognition
  • Female
  • Frailty / epidemiology*
  • Geriatric Assessment
  • Humans
  • Italy / epidemiology
  • Linear Models
  • Logistic Models
  • Male
  • Neoplasms / epidemiology*
  • Neoplasms / pathology
  • Neoplasms / physiopathology
  • Neoplasms / psychology
  • Pain / drug therapy
  • Pain / epidemiology
  • Pain / physiopathology
  • Pain / psychology
  • Pain Measurement
  • Prospective Studies
  • Sex Factors

Substances

  • Analgesics, Opioid
  • Anti-Inflammatory Agents, Non-Steroidal