Oseltamivir-induced toxic epidermal necrolysis in a patient with Cushing's disease

Indian J Dermatol Venereol Leprol. 2020 Sep-Oct;86(5):515-518. doi: 10.4103/ijdvl.IJDVL_53_18.

Abstract

We report a case of a patient with Cushing's disease with oseltamivir-induced toxic epidermal necrolysis, who was treated with cyclosporine with favorable evolution. There is only one case reported of Cushing's disease and toxic epidermal necrolysis and very few oseltamivir-induced toxic epidermal necrolysis cases in literature. This report also discusses the role that the preexisting hypercortisolism condition may have played in the development and favorable resolution of the toxic epidermal necrolysis.

Keywords: Cushing's disease; oseltamivir; toxic epidermal necrolysis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antiviral Agents / adverse effects*
  • Humans
  • Male
  • Oseltamivir / adverse effects*
  • Pituitary ACTH Hypersecretion / diagnosis*
  • Pituitary ACTH Hypersecretion / drug therapy*
  • Stevens-Johnson Syndrome / diagnosis*
  • Stevens-Johnson Syndrome / therapy

Substances

  • Antiviral Agents
  • Oseltamivir