Proinflammatory Pathways in the Pathogenesis of Asthma

R Stokes Peebles Jr; Mark A Aronica

doi:10.1016/j.ccm.2018.10.014

Proinflammatory Pathways in the Pathogenesis of Asthma

Clin Chest Med. 2019 Mar;40(1):29-50. doi: 10.1016/j.ccm.2018.10.014.

Authors

R Stokes Peebles Jr¹, Mark A Aronica²

Affiliations

¹ Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, VUMC, T-1218 MCN, 1161 21st Avenue South, Nashville, TN 37232-2650, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, VUMC, T-1218 MCN, 1161 21st Avenue South, Nashville, TN 37232-2650, USA. Electronic address: stokes.peebles@vanderbilt.edu.
² Department of Pathobiology, Respiratory Institute, Cleveland Clinic Lerner College of Medicine, CWRU, 9500 Euclid Avenue, NB2-85, Cleveland, OH 44195, USA.

Abstract

There are multiple proinflammatory pathways in the pathogenesis of asthma. These include both innate and adaptive inflammation, in addition to inflammatory and physiologic responses mediated by eicosanoids. An important component of the innate allergic immune response is ILC2 activated by interleukin (IL)-33, thymic stromal lymphopoietin, and IL-25 to produce IL-5 and IL-13. In terms of the adaptive T-lymphocyte immunity, CD4+ Th2 and IL-17-producing cells are critical in the inflammatory responses in asthma. Last, eicosanoids involved in asthma pathogenesis include prostaglandin D₂ and the cysteinyl leukotrienes that promote smooth muscle constriction and inflammation that propagate allergic responses.

Keywords: Adaptive; Asthma; Innate; Prostaglandin leukotriene.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Adaptive Immunity / immunology*
Asthma / immunology*
Asthma / physiopathology*
Humans
Immunity, Innate / immunology*

Abstract

Publication types

MeSH terms

Grants and funding