A self-assembled peptide nucleic acid-microRNA nanocomplex for dual modulation of cancer-related microRNAs

Chem Commun (Camb). 2019 Feb 12;55(14):2106-2109. doi: 10.1039/c9cc00002j.

Abstract

Here, we report a new strategy for the construction of a peptide nucleic acid-microRNA nanocomplex with dual function to simultaneously suppress oncogenic microRNAs and upregulate tumor-suppressive microRNAs in target cancer cells.

MeSH terms

  • Cell Line, Tumor
  • Gene Expression Regulation, Neoplastic
  • Gene Silencing
  • Humans
  • MicroRNAs / chemistry*
  • Microscopy, Electron, Transmission
  • Nanoparticles / chemistry*
  • Neoplasms / genetics*
  • Oncogenes
  • Peptide Nucleic Acids / chemistry*
  • Up-Regulation

Substances

  • MicroRNAs
  • Peptide Nucleic Acids