Prevalence and Antimicrobial Resistance of Mycoplasma genitalium Infection Among Women Living With Human Immunodeficiency Virus in South Africa: A Prospective Cohort Study

Clin Infect Dis. 2019 Aug 16;69(5):873-876. doi: 10.1093/cid/ciz045.

Abstract

This prospective cohort study of 622 women living with human immunodeficiency virus (HIV) from Johannesburg (2012) detected Mycoplasma genitalium in 7.4% (95% confidence interval [CI]: 5.5-9.7, 46/622), with detection more likely with lower CD4 counts(adjusted odds ratio [AOR] 1.02 per 10 cells/μL decrease, 95% CI: 1.00-1.03) and higher plasma HIV-1 RNA (AOR 1.15 per log copies/mL increase, 95% CI: 1.03-1.27). No mutations for macrolide/quinolone resistance was detected.

Keywords: Mycoplasma genitalium; HIV; antimicrobial resistance; sexually transmitted infections; women.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-Bacterial Agents / pharmacology*
  • Cervix Uteri / microbiology
  • Drug Resistance, Bacterial*
  • Female
  • HIV Infections / epidemiology*
  • HIV Infections / microbiology
  • Humans
  • Middle Aged
  • Mycoplasma Infections / epidemiology*
  • Mycoplasma Infections / virology
  • Mycoplasma genitalium / drug effects*
  • Odds Ratio
  • Prevalence
  • Prospective Studies
  • South Africa / epidemiology

Substances

  • Anti-Bacterial Agents