Controlled light-induced gas phase nitric oxide release from S-nitrosothiol-doped silicone rubber films

Gergely Lautner; Blake Stringer; Elizabeth J Brisbois; Mark E Meyerhoff; Steven P Schwendeman

doi:10.1016/j.niox.2019.01.016

Controlled light-induced gas phase nitric oxide release from S-nitrosothiol-doped silicone rubber films

Nitric Oxide. 2019 May 1:86:31-37. doi: 10.1016/j.niox.2019.01.016. Epub 2019 Feb 5.

Authors

Gergely Lautner¹, Blake Stringer², Elizabeth J Brisbois³, Mark E Meyerhoff⁴, Steven P Schwendeman⁵

Affiliations

¹ Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA.
² Department of Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA.
³ Department of Materials Science and Engineering, University of Central Florida, Orlando, FL, 32816, USA.
⁴ Department of Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA. Electronic address: mmeyerho@umich.edu.
⁵ Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, 48109, USA. Electronic address: schwende@umich.edu.

Abstract

The light induced nitric oxide (NO) release properties of S-nitroso-N-acetylpenicillamine (SNAP) and S-nitrosoglutathione (GSNO) NO donors doped within polydimethylsiloxane (PDMS) films (PDMS-SNAP and PDMS-GSNO respectively) for potential inhaled NO (iNO) applications is examined. To achieve photolytic release of gas phase NO from the PDMS-SNAP and PDMS-GSNO films, narrow-band LED light sources are employed and the NO concentration in a N₂ sweep gas above the film is monitored with an electrochemical NO sensor. The NO release kinetics using LED sources with different nominal wavelengths and optical power densities are reported. The effect of the NO donor loading within the PDMS films is also examined. The NO release levels can be controlled by the LED triggered release from the NO donor-doped silicone rubber films in order to generate therapeutic levels in a sweep gas for suitable durations potentially useful for iNO therapy. Hence this work may lay the groundwork for future development of a highly portable iNO system for treatment of patients with pulmonary hypertension, hypoxemia, and cystic fibrosis.

Keywords: GSNO; Gas phase; Inhalation NO; Nitric oxide; Photo release; S-nitrosothiol; SNAP.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Drug Carriers / chemistry*
Drug Liberation
Gases / chemistry
Kinetics
Membranes, Artificial
Nitric Oxide / chemistry*
Nitric Oxide Donors / chemistry*
Nitric Oxide Donors / radiation effects
S-Nitroso-N-Acetylpenicillamine / chemistry*
S-Nitroso-N-Acetylpenicillamine / radiation effects
S-Nitrosoglutathione / chemistry*
S-Nitrosoglutathione / radiation effects
Silicones / chemistry*
Ultraviolet Rays

Substances

Drug Carriers
Gases
Membranes, Artificial
Nitric Oxide Donors
Silicones
Nitric Oxide
S-Nitrosoglutathione
S-Nitroso-N-Acetylpenicillamine

Abstract

Publication types

MeSH terms

Substances

Grants and funding