Venetoclax penetrates in cerebrospinal fluid and may be effective in chronic lymphocytic leukemia with central nervous system involvement

Haematologica. 2019 May;104(5):e222-e223. doi: 10.3324/haematol.2018.213157. Epub 2019 Feb 14.

Authors

Gianluigi Reda¹, Ramona Cassin², Gabriela Dovrtelova^{3

4}, Cristina Matteo³, Juri Giannotta², Maurizio D'Incalci³, Agostino Cortelezzi², Massimo Zucchetti³

Affiliations

¹ Hematology Unit, IRCCS Ca' Granda Ospedale Maggiore Policlinico of Milan, Italy gianluigi.reda@policlinico.mi.it.
² Hematology Unit, IRCCS Ca' Granda Ospedale Maggiore Policlinico of Milan, Italy.
³ Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Italy.
⁴ Department of Pharmacology, Faculty of Medicine, Masaryk University and International Clinical Research Center, St. Anne's University Hospital Brno, Czech Republic.

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Antineoplastic Agents / pharmacokinetics
Antineoplastic Agents / therapeutic use*
Bridged Bicyclo Compounds, Heterocyclic / pharmacokinetics
Bridged Bicyclo Compounds, Heterocyclic / therapeutic use*
Central Nervous System Neoplasms / cerebrospinal fluid
Central Nervous System Neoplasms / complications
Central Nervous System Neoplasms / drug therapy*
Central Nervous System Neoplasms / pathology
Humans
Leukemia, Lymphocytic, Chronic, B-Cell / cerebrospinal fluid
Leukemia, Lymphocytic, Chronic, B-Cell / complications
Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy*
Leukemia, Lymphocytic, Chronic, B-Cell / pathology
Middle Aged
Neoplasm Recurrence, Local / cerebrospinal fluid
Neoplasm Recurrence, Local / drug therapy*
Neoplasm Recurrence, Local / pathology
Prognosis
Sulfonamides / pharmacokinetics
Sulfonamides / therapeutic use*
Tissue Distribution

Substances

Antineoplastic Agents
Bridged Bicyclo Compounds, Heterocyclic
Sulfonamides
venetoclax