Safety of 80% vs 30-35% fraction of inspired oxygen in patients undergoing surgery: a systematic review and meta-analysis

Abstract

Background: Evidence-based guidelines from the World Health Organization (WHO) have recommended a high (80%) fraction of inspired oxygen (FiO₂) to reduce surgical site infection in adult surgical patients undergoing general anaesthesia with tracheal intubation. However, there is ongoing debate over the safety of high FiO₂. We performed a systematic review to define the relative risk of clinically relevant adverse events (AE) associated with high FiO₂.

Methods: We reviewed potentially relevant articles from the WHO review supporting the recommendation, including an updated (July 2018) search of EMBASE and PubMed for randomised and non-randomised controlled studies reporting AE in surgical patients receiving 80% FiO₂ compared with 30-35% FiO₂. We assessed study quality and performed meta-analyses of risk ratios (RR) comparing 80% FiO₂ against 30-35% for major complications, mortality, and intensive care admission.

Results: We included 17 moderate-good quality trials and two non-randomised studies with serious-critical risk of bias. No evidence of harm with high FiO₂ was found for major AE in the meta-analysis of randomised trials: atelectasis RR 0.91 [95% confidence interval (CI) 0.59-1.42); cardiovascular events RR 0.90 (95% CI 0.32-2.54); intensive care admission RR 0.93 (95% CI 0.7-1.12); and death during the trial RR 0.49 (95% CI 0.17-1.37). One non-randomised study reported that high FiO₂ was associated with major respiratory AE [RR 1.99 (95% CI 1.72-2.31)].

Conclusions: No definite signal of harm with 80% FiO₂ in adult surgical patients undergoing general anaesthesia was demonstrated and there is little evidence on safety-related issues to discourage its use in this population.

Keywords: adverse events; general anaesthesia; high FiO(2); hyperoxia; peri-operative outcome; surgical site infection; surgical wound infection.