A Feedback Loop Controlling Organ Size

Allyson J Merrell; Ben Z Stanger

doi:10.1016/j.devcel.2019.02.008

A Feedback Loop Controlling Organ Size

Dev Cell. 2019 Feb 25;48(4):425-426. doi: 10.1016/j.devcel.2019.02.008.

Authors

Allyson J Merrell¹, Ben Z Stanger²

Affiliations

¹ Departments of Medicine and Cellular and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
² Departments of Medicine and Cellular and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: bstanger@upenn.edu.

PMID: 30782410
DOI: 10.1016/j.devcel.2019.02.008

Abstract

To maintain proper organ size, nature has devised trans-organ communication systems-involving both paracrine and circulating regulatory factors-to safeguard homeostasis. In this issue of Developmental Cell, Ji et al. (2019) now describe an enterohepatic feedback loop that balances tissue size and function in the mammalian liver.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Bile Acids and Salts
Carcinogenesis*
Liver
Organ Size
Signal Transduction*

Substances

Bile Acids and Salts