Bridges between Antimalarials and Synaptic Transmission

Neuron. 2019 Feb 20;101(4):546-547. doi: 10.1016/j.neuron.2019.01.057.

Abstract

Gephyrin-mediated clustering of GABAA and glycine receptors underlies fast inhibitory signaling at central synapses. In this issue of Neuron, Kasaragod et al. (2019) demonstrate that artemisinin antimalarial drugs bind to gephyrin at the same site where the receptor interaction occurs.

Publication types

  • Comment

MeSH terms

  • Antimalarials*
  • Artemisinins*
  • Receptors, GABA-A
  • Receptors, Glycine
  • Synapses
  • Synaptic Transmission

Substances

  • Antimalarials
  • Artemisinins
  • Receptors, GABA-A
  • Receptors, Glycine