Expansion deficiency of CAR-T cells in patients with lymphoma and resolution by T cell purification

Br J Haematol. 2019 Jul;186(2):340-343. doi: 10.1111/bjh.15822. Epub 2019 Mar 4.

Authors

Lvzhe Chen¹, Shiqi Li², Meiling Wang³, Yunyan Li³, Zhouxing Xiong³, Rui Zhang³, Yanmin Xu³, Zixuan Huang³, Linling Wang³, Sanbin Wang², Zhi Yang³, Cheng Qian^{1

3}

Affiliations

¹ College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, Zhejiang Province, China.
² Haematology Department, Kunming General Hospital of PLA, Kunming, Yunnan Province, China.
³ Centre of Biological Therapy, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.

PMID: 30834515
DOI: 10.1111/bjh.15822

No abstract available

Keywords: CAR-T; T cell purity; cell manufacture; lymphoma.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Cell Culture Techniques
Cell Proliferation*
Cell Separation*
Humans
Lymphoma* / blood
Lymphoma* / pathology
Receptors, Chimeric Antigen / blood*
T-Lymphocytes* / metabolism
T-Lymphocytes* / pathology

Substances

Receptors, Chimeric Antigen