Lack of Toxicity With Long-term Isavuconazole Use in Patients With Hematologic Malignancy

Clin Infect Dis. 2019 Oct 15;69(9):1624-1627. doi: 10.1093/cid/ciz159.

Abstract

Prolonged courses of isavuconazole (ISA) are increasingly utilized in immunocompromised patients. Toxicities have been reported with long-term use of the other triazoles. We report the first real-life tolerability data in 50 patients with hematologic malignancy receiving ≥6 months of ISA. ISA was well tolerated in our ill patient population.

Keywords: hematologic malignancy; invasive mold infections; isavuconazole; toxicity.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antifungal Agents / adverse effects
  • Antifungal Agents / therapeutic use
  • Female
  • Hematologic Neoplasms / drug therapy*
  • Humans
  • Liver / drug effects
  • Male
  • Middle Aged
  • Nitriles / adverse effects*
  • Nitriles / therapeutic use*
  • Pyridines / adverse effects*
  • Pyridines / therapeutic use*
  • Retrospective Studies
  • Skin / drug effects
  • Triazoles / adverse effects*
  • Triazoles / therapeutic use*
  • Young Adult

Substances

  • Antifungal Agents
  • Nitriles
  • Pyridines
  • Triazoles
  • isavuconazole