The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with [11C]-Pittsburgh compound B PET computed tomography in patients with a normal cognitive function

Ann Nucl Med. 2019 Jul;33(7):541-544. doi: 10.1007/s12149-019-01349-6. Epub 2019 Mar 18.

Abstract

Objective: Disturbed sleep due to obstructive sleep apnea syndrome (OSAS) might accelerate amyloidβ (Aβ) deposition, which can be a crucial factor in Alzheimer's disease. We studied Aβ deposition in untreated OSAS patients with normal cognition.

Method: We performed polysomnography (PSG) and Aβ imaging with [11C]-Pittsburgh compound B PET computed tomography (11C-PiB PET CT) in 14 untreated OSAS patients (apnea-hypopnea index: 43.8 ± 26.3/h).

Results: The abnormal accumulation of enhanced 11C-PiB PET was observed only one patient with severe, but not the most severe.

Conclusions: The OSAS severity alone may not predict Aβ deposition in OSAS patients with normal cognition.

Keywords: Amyloidβ; Obstructive sleep apnea syndrome; Polysomnography; [11C]-Pittsburgh compound B PET computed tomography.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Amyloid / metabolism*
  • Aniline Compounds*
  • Brain / diagnostic imaging
  • Brain / metabolism*
  • Brain / physiopathology
  • Cognition*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Positron Emission Tomography Computed Tomography*
  • Sleep Apnea, Obstructive / diagnostic imaging*
  • Sleep Apnea, Obstructive / metabolism*
  • Sleep Apnea, Obstructive / physiopathology
  • Thiazoles*

Substances

  • 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
  • Amyloid
  • Aniline Compounds
  • Thiazoles