The spread of the action potential through the T-system in hagfish twitch muscle fibres

Acta Physiol Scand. 1976 Jan;96(1):29-49. doi: 10.1111/j.1748-1716.1976.tb10168.x.

Abstract

The input impedance of twitch muscle fibres of the Atlantic hagfish has been measured with sinusoidal transmembrane currents. The apparent specific membrane resistance and capacitance decreased markedly with frequency, and were relatively independent of fibre diameter. A model of the T-system based on anatomical observations, was used to predict the input impedance in the normal solution (artificial sea water). The changes in input impedance produced by glycerol treatment, low chloride solution, reduced pH and isotonic solutions with low ionic strength were easily interpreted in terms of the same model. The model predicts severe attenuation of the action potential if conducted electrotonically by the transverse tubules towards the center of the fibre.

MeSH terms

  • Action Potentials* / drug effects
  • Animals
  • Chlorides / pharmacology
  • Electric Stimulation
  • Fishes* / physiology*
  • Glycerol / pharmacology
  • Hagfishes* / physiology*
  • Hydrogen-Ion Concentration
  • Membrane Potentials / drug effects
  • Models, Biological
  • Muscle Contraction* / drug effects
  • Muscles / drug effects
  • Muscles / physiology*
  • Neuromuscular Junction / physiology
  • Osmolar Concentration
  • Sarcolemma / physiology
  • Sucrose / pharmacology

Substances

  • Chlorides
  • Sucrose
  • Glycerol