Mantle zone lymphoma with central nervous system involvement

Cancer. 1986 Nov 1;58(9):2125-9. doi: 10.1002/1097-0142(19861101)58:9<2125::aid-cncr2820580927>3.0.co;2-t.

Abstract

A 68-year-old man with a 7-year history of lymphocytosis and lymphadenopathy is described. Accelerated disease, indicated by bilateral optic nerve and cerebrospinal fluid involvement, prompted thorough histologic and immunologic assessment. Although initially believed to have chronic lymphocytic leukemia (CLL), results showed mantle zone lymphoma (MZL) with central nervous system (CNS) involvement. The authors believe that this represents the first case of MZL with CNS involvement.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Brain Neoplasms / immunology
  • Brain Neoplasms / pathology*
  • Cranial Nerve Neoplasms / pathology
  • Diagnosis, Differential
  • Histocytochemistry
  • Humans
  • Immunoenzyme Techniques
  • Immunoglobulin M / analysis
  • Immunoglobulin kappa-Chains / analysis
  • Leukemia, Lymphocytic, Chronic, B-Cell / pathology
  • Leukemia, Lymphoid / pathology
  • Lymph Nodes / pathology*
  • Lymphatic Metastasis
  • Lymphoma / immunology
  • Lymphoma / pathology*
  • Male
  • Optic Nerve Diseases / pathology
  • Spinal Cord Neoplasms / immunology
  • Spinal Cord Neoplasms / pathology*

Substances

  • Immunoglobulin M
  • Immunoglobulin kappa-Chains