Acute exacerbation of interstitial lung disease after procedures

William H Amundson; Emilian Racila; Tadashi Allen; H Erhan Dincer; Rade Tomic; Maneesh Bhargava; David M Perlman; Hyun Joo Kim

doi:10.1016/j.rmed.2019.02.012

Acute exacerbation of interstitial lung disease after procedures

Respir Med. 2019 Apr:150:30-37. doi: 10.1016/j.rmed.2019.02.012. Epub 2019 Feb 12.

Authors

William H Amundson¹, Emilian Racila², Tadashi Allen³, H Erhan Dincer¹, Rade Tomic⁴, Maneesh Bhargava¹, David M Perlman¹, Hyun Joo Kim⁵

Affiliations

¹ Department of Medicine, Division of Pulmonary, Allergy, Critical Care, and Sleep, University of Minnesota, Minneapolis, MN, United States.
² Department of Pathology, University of Minnesota, Minneapolis, MN, United States.
³ Department of Radiology, University of Minnesota, Minneapolis, MN, United States.
⁴ Department of Medicine, Division of Pulmonary and Critical Care, Northwestern University, Chicago, IL, United States.
⁵ Department of Medicine, Division of Pulmonary, Allergy, Critical Care, and Sleep, University of Minnesota, Minneapolis, MN, United States. Electronic address: kimxx015@umn.edu.

PMID: 30961948
DOI: 10.1016/j.rmed.2019.02.012

Abstract

Interstitial lung disease (ILD) is a category of diffuse parenchymal lung diseases characterized by inflammation and/or fibrosis. The best characterized ILD is idiopathic pulmonary fibrosis (IPF). Acute exacerbation of IPF is a dreaded occurrence with grim prognosis and suboptimal treatment options. There have been recent reports that acute exacerbation can occur in other ILDs (AE-ILD). Of note, some of these acute exacerbations follow lung procedures. This review summarizes the available information on AE-ILD and discusses the procedures reported to cause AE-ILD. We also discuss proposed mechanisms, risk factors, treatment and prognosis. This review should help to inform decision-making about risks versus benefits of procedures that are commonly recommended to diagnose ILD.

Keywords: AE-ILD; Acute exacerbation; Acute exacerbation of interstitial lung disease; Interstitial lung disease; Lung biopsy.

Publication types

Comparative Study
Review

MeSH terms

Aged
Biopsy / adverse effects*
Bronchoalveolar Lavage / adverse effects
Bronchoscopy / adverse effects
Disease Progression
Female
Humans
Hyperoxia / complications
Idiopathic Pulmonary Fibrosis / diagnostic imaging
Idiopathic Pulmonary Fibrosis / etiology*
Idiopathic Pulmonary Fibrosis / mortality
Idiopathic Pulmonary Fibrosis / physiopathology
Lung / pathology
Lung Diseases, Interstitial / diagnostic imaging
Lung Diseases, Interstitial / etiology*
Lung Diseases, Interstitial / mortality
Lung Diseases, Interstitial / physiopathology
Male
Middle Aged
Prognosis
Respiratory Function Tests / methods
Risk Factors
Tomography, X-Ray Computed / methods