Escherichia coli Harboring mcr-1 in a Cluster of Liver Transplant Recipients: Detection through Active Surveillance and Whole-Genome Sequencing

Antimicrob Agents Chemother. 2019 May 24;63(6):e02680-18. doi: 10.1128/AAC.02680-18. Print 2019 Jun.

Abstract

mcr-1, a plasmid-associated gene for colistin resistance, was first described in China in 2015, but its spread in the United States is unknown. We report detection of mcr-1-carrying Escherichia coli ST117 in a cluster of three liver transplant recipients.

Keywords: antimicrobial resistance; colistin; mcr-1; polymyxin B; whole-genome sequencing.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Colistin / pharmacology*
  • Drug Resistance, Bacterial / genetics
  • Escherichia coli / drug effects
  • Escherichia coli / genetics
  • Escherichia coli Proteins / genetics
  • Escherichia coli Proteins / metabolism
  • Liver Transplantation
  • Plasmids / genetics
  • Whole Genome Sequencing / methods

Substances

  • Escherichia coli Proteins
  • Colistin