Antibacterial Property and Cytotoxicity of a Poly(lactic acid)/Nanosilver-Doped Multiwall Carbon Nanotube Nanocomposite

Chi-Hui Tsou; Wei-Hua Yao; Yi-Cheng Lu; Chih-Yuan Tsou; Chin-San Wu; Jian Chen; Ruo Yao Wang; Chaochin Su; Wei-Song Hung; Manuel De Guzman; Maw-Cherng Suen

doi:10.3390/polym9030100

Antibacterial Property and Cytotoxicity of a Poly(lactic acid)/Nanosilver-Doped Multiwall Carbon Nanotube Nanocomposite

Polymers (Basel). 2017 Mar 10;9(3):100. doi: 10.3390/polym9030100.

Authors

Chi-Hui Tsou^{1

2

3}, Wei-Hua Yao⁴, Yi-Cheng Lu⁵, Chih-Yuan Tsou^{6

7}, Chin-San Wu⁸, Jian Chen⁹, Ruo Yao Wang¹⁰, Chaochin Su¹¹, Wei-Song Hung¹², Manuel De Guzman¹³, Maw-Cherng Suen¹⁴

Affiliations

¹ Material Corrosion and Protection Key Laboratory of Sichuan Province, College of Materials Science and Engineering, Sichuan University of Science and Engineering, Zigong 643000, China. mayko0301@hotmail.com.
² Faculties of Biological and Chemical Engineering, Faculties of Materials Engineering, Science and Technology Innovation Center, Panzhihua University, Panzhihua 617000, China. mayko0301@hotmail.com.
³ Department of Materials Science, Chulalongkorn University, Bangkok 10330, Thailand. mayko0301@hotmail.com.
⁴ Department of Materials and Textiles, Oriental Institute of Technology, New Taipei City 22061, Taiwan. angelayao@mail.oit.edu.tw.
⁵ Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan. b10104003@mail.ntust.edu.tw.
⁶ Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan. keymykimo@gmail.com.
⁷ Faculty of Electronic and Electrical Engineering, Huaiyin Institute of Technology, Huan'an 223003, China. keymykimo@gmail.com.
⁸ Department of Applied Cosmetology, Kao Yuan University, Kaohsiung 82101, Taiwan. cws1222@cc.kyu.edu.tw.
⁹ Material Corrosion and Protection Key Laboratory of Sichuan Province, College of Materials Science and Engineering, Sichuan University of Science and Engineering, Zigong 643000, China. jchenzg@aliyun.com.
¹⁰ Department of Molecular Science & Engineering, National Taipei University of Technology, Taipei 10608, Taiwan. steven5202001@yahoo.com.tw.
¹¹ Department of Molecular Science & Engineering, National Taipei University of Technology, Taipei 10608, Taiwan. f10913@ntut.edu.tw.
¹² Center for Membrane Technology, Chung Yuan University, Taoyuan 32023, Taiwan. wshung@cycu.edu.tw.
¹³ Center for Membrane Technology, Chung Yuan University, Taoyuan 32023, Taiwan. ounnam@gmail.com.
¹⁴ Department of Fashion Business Administration, Lee-Ming Institute of Technology, Taishan, New Taipei City 24305, Taiwan. sun@tiit.edu.tw.

Abstract

A novel method was used to synthesize a nanosilver-doped multiwall carbon nanotube (MWCNT-Ag), and subsequently, the novel poly(lactic acid) (PLA)- and MWCNT-Ag-based biocompatible and antimicrobial nanocomposites were prepared by melt blending. Based on energy dispersive X-ray spectrometry images, an MWCNT-Ag was successfully synthesized. The effect of the MWCNT-Ag on the PLA bionanocomposites was investigated by evaluating their thermal and mechanical properties, antifungal activity, and cytotoxicity. The nanocomposites exhibited a high degree of biocompatibility with the MWCNT-Ag content, which was less than 0.3 phr. Furthermore, tensile strength testing, thermogravimetric analysis, differential scanning calorimetry, and antibacterial evaluation revealed that the tensile strength, thermostability, glass transition temperature, and antibacterial properties were enhanced by increasing the MWCNT-Ag content. Finally, hydrolysis analysis indicated that the low MWCNT-Ag content could increase the packing density of PLA.

Keywords: antibacterial property; bionanocomposites; cytotoxicity; nanosilver-doped multiwall carbon nanotube; poly(lactic acid).

Grants and funding

National Natural Science Foundation of China