The Collaborative Cross: A Systems Genetics Resource for Studying Host-Pathogen Interactions

Kelsey E Noll; Martin T Ferris; Mark T Heise

doi:10.1016/j.chom.2019.03.009

The Collaborative Cross: A Systems Genetics Resource for Studying Host-Pathogen Interactions

Cell Host Microbe. 2019 Apr 10;25(4):484-498. doi: 10.1016/j.chom.2019.03.009.

Authors

Kelsey E Noll¹, Martin T Ferris², Mark T Heise³

Affiliations

¹ Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
² Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: mtferris@email.unc.edu.
³ Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: mark_heisem@med.unc.edu.

Abstract

Host genetic variation has a major impact on infectious disease susceptibility. The study of pathogen resistance genes, largely aided by mouse models, has significantly advanced our understanding of infectious disease pathogenesis. The Collaborative Cross (CC), a newly developed multi-parental mouse genetic reference population, serves as a tractable model system to study how pathogens interact with genetically diverse populations. In this review, we summarize progress utilizing the CC as a platform to develop improved models of pathogen-induced disease and to map polymorphic host response loci associated with variation in susceptibility to pathogens.

Keywords: Collaborative Cross; genetics reference populations; immune genes; immunity; infection.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Communicable Diseases / pathology*
Disease Models, Animal
Genetic Predisposition to Disease*
Genetic Variation*
Host-Pathogen Interactions*
Mice
Systems Biology / methods*

Abstract

Publication types

MeSH terms

Grants and funding