A Long-term Survival after Surgical Treatment for Atypical Aortic Coarctation Complicating Takayasu Arteritis with Inactive Disease at the Diagnosis: An Appropriately Treated Autopsy Case

Intern Med. 2019 Aug 1;58(15):2241-2246. doi: 10.2169/internalmedicine.2483-18. Epub 2019 Apr 17.

Abstract

The number of Takayasu arteritis (TAK) cases being diagnosed at an advanced age has increased, including some who develop ischemic lesions without inflammation of the involved arteries long after the onset of TAK. However, few histopathological analyses of such patients without immunosuppressive therapy have been reported. We herein report a 92-year-old woman with atypical aortic coarctation complicating TAK who underwent bypass graft surgery and survived for 23 years without immunosuppressive therapy. Microscopic findings at the autopsy revealed clear differences between the affected and unaffected arteries. This case suggests that inflammation severe enough to destroy the structure of the aorta may not inherently be sufficient to promote systemic atherosclerosis.

Keywords: Takayasu arteritis; atypical aortic coarctation; inactive disease.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Aorta / pathology
  • Aortic Coarctation / complications*
  • Aortic Coarctation / surgery
  • Autopsy
  • Coronary Artery Bypass
  • Female
  • Humans
  • Inflammation / complications*
  • Takayasu Arteritis / complications*
  • Vascular Surgical Procedures / adverse effects