Possible Mechanism of Hematocrit Elevation by Sodium Glucose Cotransporter 2 Inhibitors and Associated Beneficial Renal and Cardiovascular Effects

Circulation. 2019 Apr 23;139(17):1985-1987. doi: 10.1161/CIRCULATIONAHA.118.038881.
No abstract available

Keywords: cell transdifferentiation; heart failure; hematocrit; hypoxia; sodium-potassium pump; sympathetic nervous system.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Cell Hypoxia / drug effects
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / drug therapy
  • Diabetic Cardiomyopathies / drug therapy
  • Diabetic Cardiomyopathies / prevention & control
  • Diabetic Nephropathies / drug therapy
  • Diabetic Nephropathies / prevention & control
  • Disease Progression
  • Diuresis / drug effects
  • Erythropoiesis / drug effects*
  • Erythropoietin / biosynthesis
  • Erythropoietin / genetics
  • Gene Expression Regulation / drug effects
  • Glucose / metabolism
  • Heart / drug effects*
  • Heart Failure / etiology
  • Heart Failure / prevention & control
  • Hematocrit*
  • Hemoglobins / biosynthesis
  • Hemoglobins / genetics
  • Humans
  • Kidney / drug effects*
  • Kidney Tubules, Proximal / metabolism
  • Renal Insufficiency, Chronic / etiology
  • Renal Insufficiency, Chronic / metabolism
  • Renal Insufficiency, Chronic / prevention & control
  • Sodium-Glucose Transporter 2 Inhibitors / pharmacology*
  • Sodium-Glucose Transporter 2 Inhibitors / therapeutic use
  • Sodium-Potassium-Exchanging ATPase / metabolism
  • Sympathetic Nervous System / drug effects
  • Sympathetic Nervous System / physiopathology

Substances

  • EPO protein, human
  • Hemoglobins
  • Sodium-Glucose Transporter 2 Inhibitors
  • Erythropoietin
  • Adenosine Triphosphate
  • Sodium-Potassium-Exchanging ATPase
  • Glucose