High School Start Time and Migraine Frequency in High School Students

Amy A Gelfand; Sara Pavitt; Kaitlin Greene; Christina L Szperka; Samantha Irwin; Barbara Grimes; Isabel E Allen

doi:10.1111/head.13535

High School Start Time and Migraine Frequency in High School Students

Headache. 2019 Jul;59(7):1024-1031. doi: 10.1111/head.13535. Epub 2019 Apr 24.

Authors

Amy A Gelfand¹, Sara Pavitt², Kaitlin Greene¹, Christina L Szperka^{3

4}, Samantha Irwin¹, Barbara Grimes⁵, Isabel E Allen⁵

Affiliations

¹ Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
² Department of Neurology, Stanford University Hospital and Clinics, Palo Alto, CA, USA.
³ Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
⁴ Departments of Neurology & Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
⁵ Department of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, CA, USA.

Abstract

Objective: To investigate whether later high school start time is associated with lower migraine frequency in high school students with migraine.

Background: Adequate sleep is thought to be important in managing adolescent migraine. The American Academy of Sleep Medicine recommends teenagers sleep ≥8 hours/night. Adolescents have a physiologically delayed sleep phase, going to bed, and waking later than children and adults. The American Academy of Pediatrics (AAP) accordingly recommends high schools start no earlier than 8:30 AM.

Methods: Cross-sectional observational study of U.S. high schoolers with migraine. Participants were recruited nationally using social media. Respondents attending high schools starting at 8:30 AM or later were compared to those attending earlier start time schools. The primary outcome was headache days/month.

Results: Two hundred and fifty-six subjects constituted the analysis set: 115 later group vs 141 earlier group. Age and sex did not differ. Mean (SD) self-reported headache days/month were 7 (5) vs 8 (7), respectively, (P = .985); mean difference (95% CI for the difference) was -0.8 (-2.3-0.7) days. Median (IQR) self-reported total hours of sleep/school night were: 5.6 (5.0-6.6) vs 5.6 (4.5-6.4), P = .058. Students attending later start time schools woke later (median [IQR] 6:38 AM [55 minutes] vs 6:09 AM [59 minutes], P < .0001) and left home later (median [IQR] 7:28 AM [28 minutes] vs 7:02 AM [60 minutes], P < .0001). Average commute time was also longer: 41 (21) minutes vs 28 (16), P < .0001. The vast majority in both groups reported missing breakfast at least once/week: 103/114 (90.4%) vs 128/141 (90.8%), P = .907. Hours of sleep did not correlate with headache days per month.

Conclusion: High school start time does not have a large effect on headache frequency in high schoolers with migraine. Given the high variance in headache days/month observed in this study, a larger study would be needed to determine whether there might still be a small effect of starting high school at/after 8:30 AM. More research is needed to establish evidence-based recommendations about lifestyle factors in adolescent migraine management.

Trial registration: ClinicalTrials.gov NCT03766412.

Keywords: adolescent; migraine; sleep.

Publication types

Observational Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Cross-Sectional Studies
Female
Humans
Male
Migraine Disorders / epidemiology
Migraine Disorders / physiopathology*
Schools* / statistics & numerical data
Sleep / physiology*
Students* / statistics & numerical data
Time Factors
United States / epidemiology
Wakefulness / physiology*

Associated data

ClinicalTrials.gov/NCT03766412

Abstract

Publication types

MeSH terms

Associated data

Grants and funding