Unmet therapeutic goals and potential treatable traits in a population of patients with severe uncontrolled asthma in Spain. ENEAS study

Luis Pérez de Llano; Eva Martínez-Moragón; Vicente Plaza Moral; Andrea Trisan Alonso; Carlos Almonacid Sánchez; Francisco Javier Callejas; Elisabeth Vera; Jose Gregorio Soto Campos; Carlos Martinez Rivera; Bernardino Alcázar Navarrete; Isabel Urrutia Landa; Juan Luis Garcia Rivero; Alicia Padilla Galo; Francisco Alvarez Gutierrez; Pedro Landete; Jacinto Ramos González; Cleofé Fernández Aracil; José Ángel Carretero Gracia; Inmaculada Lluch; Luis Puente; Ruben Andujar-Espinosa; Borja Garcia Cosío

doi:10.1016/j.rmed.2019.03.006

Unmet therapeutic goals and potential treatable traits in a population of patients with severe uncontrolled asthma in Spain. ENEAS study

Respir Med. 2019 May:151:49-54. doi: 10.1016/j.rmed.2019.03.006. Epub 2019 Apr 1.

Authors

Luis Pérez de Llano¹, Eva Martínez-Moragón², Vicente Plaza Moral³, Andrea Trisan Alonso⁴, Carlos Almonacid Sánchez⁵, Francisco Javier Callejas⁶, Elisabeth Vera⁷, Jose Gregorio Soto Campos⁸, Carlos Martinez Rivera⁹, Bernardino Alcázar Navarrete¹⁰, Isabel Urrutia Landa¹¹, Juan Luis Garcia Rivero¹², Alicia Padilla Galo¹³, Francisco Alvarez Gutierrez¹⁴, Pedro Landete¹⁵, Jacinto Ramos González¹⁶, Cleofé Fernández Aracil¹⁷, José Ángel Carretero Gracia¹⁸, Inmaculada Lluch¹⁹, Luis Puente²⁰, Ruben Andujar-Espinosa²¹, Borja Garcia Cosío²²

Affiliations

¹ Pneumology Service, Hospital Universitario Lucus Augusti, EOXI Lugo, Cervo e Monforte, Spain Grupo BIOCHUS, Instituto de Investigación Sanitaria Santiago de Compostela (IDIS), Spain.
² Pneumology Service, Hospital Universitario Doctor Peset, Valencia, Spain. Electronic address: evamartinezmoragon@gmail.com.
³ Department of Respiratory Medicine, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomédica Sant Pau (IIB Sant Pau), Universitat Autònoma de Barcelona, Department of Medicine, Barcelona, Spain.
⁴ Hospital Universitario Puerta de Hierro, Madrid, Spain.
⁵ Hospital Ramón y Cajal, Madrid, Madrid, Spain.
⁶ Complejo Hospitalario Universitario de Albacete, Albacete, Albacete, Spain.
⁷ Hospital Universitario Miguel Servet, Zaragoza, Spain.
⁸ Hospital de Jerez, Jerez, Cádiz, Spain.
⁹ Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain.
¹⁰ Hospital de Loja, Loja, Granada, Spain.
¹¹ Hospital de Galdakao, Galdakao, Vizcaya, Spain.
¹² Hospital de Laredo, Laredo, Cantabria, Spain.
¹³ Hospital de Costa del Sol, Marbella, Málaga, Spain.
¹⁴ Hospital Virgen del Rocío, Sevilla, Sevilla, Spain.
¹⁵ Hospital La Princesa, Madrid, Spain.
¹⁶ Hospital Universitario de Salamanca, Salamanca, Salamanca, Spain.
¹⁷ Hospital General de Alicante, Alicante, Alicante, Spain.
¹⁸ Hospital Royo Villanova, Zaragoza, Spain.
¹⁹ Hospital La Ribera, Alcira, Valencia, Spain.
²⁰ Hospital General Universitario Gregorio Marañón, Madrid, Spain.
²¹ Hospital Clinico Universitario Virgen de la Arrixaca, Murcia, Spain.
²² Hospital Universitario Son Espases-IdISBa-CIBERES, Palma de Mallorca, Islas Baleares, Spain.

PMID: 31047117
DOI: 10.1016/j.rmed.2019.03.006

No abstract available

Keywords: Control asthma; IL-8; Serum biomarkers; Severe asthma; Therapeutic goals; Treatable traits.

Publication types

Multicenter Study
Observational Study
Research Support, Non-U.S. Gov't

MeSH terms

Airway Obstruction / epidemiology
Asthma / drug therapy*
Asthma / epidemiology*
Biomarkers / blood
Bronchial Diseases / epidemiology
Comorbidity
Cross-Sectional Studies
Eosinophilia / epidemiology
Female
Glucocorticoids / therapeutic use
Goals
Humans
Interleukin-8 / blood
Male
Medication Adherence
Middle Aged
Nebulizers and Vaporizers
Severity of Illness Index
Spain / epidemiology

Substances

Biomarkers
Glucocorticoids
Interleukin-8